Glycogen Synthase Kinase-3b Is a Prosurvival Signal for the Maintenance of Human Mast Cell Homeostasis
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Glycogen synthase kinase-3β is a prosurvival signal for the maintenance of human mast cell homeostasis.
Homeostasis of mature tissue-resident mast cells is dependent on the relative activation of pro- and antiapoptotic regulators. In this study, we investigated the role of glycogen synthase kinase 3β (GSK3β) in the survival of neoplastic and nonneoplastic human mast cells. GSK3β was observed to be phosphorylated at the Y(216) activating residue under resting conditions in both the neoplastic HMC1...
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